This project focuses on the cleaning process of the pharmaceutical powder production line of a pharmaceutical company in Jiaxing, Zhejiang, with our company (hereinafter referred to as "XX") providing a complete CIP (Clean-in-Place) online cleaning system solution. The company mainly produces highly active pharmaceutical powders and has strict requirements for equipment cleanliness, automation level, and cross-contamination control between batches. By introducing a customized CIP cleaning unit, automatic cleaning and drying of powder conveying pipelines, mixing containers, and discharge systems have been achieved, improving production efficiency and hygiene standards.

Customer pain points

Before project implementation, the client faced multiple challenges:
1. Traditional manual disassembly and cleaning methods are time-consuming and labor-intensive, with each cleaning cycle lasting 4-6 hours, seriously affecting capacity utilization.
2. Chemical powders have strong adhesion, small particle size, and are prone to dust generation. Manual operation makes it difficult to fully remove residues, resulting in a high risk of cross-contamination between batches.
3. The cleaning process requires large amounts of purified water and cleaning agents, but lacks precise control, resulting in high water consumption and increased wastewater treatment costs.
4. Unable to meet the stringent requirements of GMP (Good Manufacturing Practice) for cleaning verification, especially the lack of real-time recording and traceability for key parameters such as flow, temperature, and time.

Product advantages and solutions

To address these pain points, a certain company offers an integrated CIP cleaning system, with main features including:
1.Modular design: The system consists of a cleaning tank, heating unit, circulation pump, pneumatic valve, and PLC control system, allowing flexible deployment according to production line layout without the need for major modifications to existing equipment.
2.Automated cleaning procedures: Multiple preset cleaning modes (such as pre-rinse, alkaline wash, acid wash, final rinse, drying), with one-touch start and automatic execution, reducing single cleaning time to 1.5 hours and increasing efficiency by over 60%.
3.Relatively accurate parameter control: Real-time monitoring of cleaning liquid flow rate, temperature, and pressure through electromagnetic flowmeters, temperature sensors, and pressure transmitters helps ensure consistent cleaning results at each station, while reducing water and chemical usage by about 35%.
4.Traceability:P LC system automatically records complete data for each cleaning session (time, temperature, flow rate, batch number), supports exporting reports, and meets GMP compliance audit requirements.
5.Explosion-proof and sealing design: To address the flammability and explosion characteristics of pharmaceutical powders, all electrical components are certified for explosion-proof rating, and pipeline connections are sealed with sanitary-grade clamps to prevent dust leakage.